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Microbiology Research
Volume 15
Issue 2
10.3390/microbiolres15020041
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Case Report
Peer-Review Record

First Molecular Detection and Characterization of Fowl Aviadenovirus Serotype 11 from Broiler Chickens in Chile

Microbiol. Res. 2024, 15(2), 626-633; https://doi.org/10.3390/microbiolres15020041
by Leandro Cádiz 1,2, Miguel Guzmán 1,2, Fernando Navarrete 2, Paulina Torres 2 and Hector Hidalgo 2,*
Reviewer 1:
Sujit Mohanty
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Microbiol. Res. 2024, 15(2), 626-633; https://doi.org/10.3390/microbiolres15020041
Submission received: 8 March 2024 / Revised: 2 April 2024 / Accepted: 4 April 2024 / Published: 23 April 2024
(This article belongs to the Special Issue Evolution of Viral Virulence)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The authors made a good attempt to characterize the fowl adeno virus through this case report. Just need some minor editing as mentioned in the comment sections in the attached draft. 

Comments for author File: Comments.pdf

Comments on the Quality of English Language

English looks OK, needs few minor editing.

Author Response

Thank you very much for taking the time to review this manuscript. Please find the detailed responses below and the corresponding revisions/corrections highlighted/in track changes in the re-submitted files.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

Dear authors

Minor considerations need to be discussed.

The inclusion of a histopathologic study of the IBH cases are encouraged, if possible. Microscopic evaluation of livers with IBH-gross compatible lesions is necessary to determine the presence of basophilic intranuclear inclusion bodies, and link with gross lesions, PCR, sequencing and phylogenetic analysis.

The authors are also recommended to avoid the comparison and contrast with previously reports in which IBH/hydropericardium syndrome gross or microscopic findings were not included (e.g. Santander-Parra et al., 2023). Mixing the evaluation of FAdV isolates from both birds with and without IBH/hydropericardium syndrome lesions could drive to a wrong direction of the characterization of this viral agent.

 

Author Response

Thank you very much for taking the time to review this manuscript. Please find the detailed responses below and the corresponding revisions/corrections highlighted/in track changes in the re-submitted files.

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

It is scientifically significant to know the prevalance of FAdV around the planet. I would recommend the author to confirm the PCR results with one more (or two more) pair of primers specific for FAdV. 

Line 144,145: The author hasnt explained the Negative control. Is it just the uninfected liver extract?

Author Response

Thank you very much for taking the time to review this manuscript. Please find the detailed responses below and the corresponding revisions/corrections highlighted/in track changes in the re-submitted files.

Author Response File: Author Response.pdf

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