Stem Cell Bioprocessing

Dear Colleagues,

Over the last couple of years, with the development of innovative technologies and an increased drive for sustainability, stem cells-based applications have widened to now include alternative foods and leather products alongside biotherapeutics. However, and regardless of the application, there is a need to ensure that reliable and cost-effective bioprocesses are in place for manufacturing the stem cells and their products (e.g., extracellular vesicles, differentiated cells etc). This interdisciplinary research is complex as it sits at the intersection between engineering and life sciences, and as such, it requires knowledge and expertise from both disciplines.

This Special Issue of Bioengineering focusing on Stem Cell Bioprocessing aims to showcase the latest research in the form of original papers and comprehensive reviews on new approaches to manufacturing stem cells to tackle the existing challenges of scale-up, reproducibility and cost-effectiveness, as well as innovations in bioprocessing tools for stem cell production (e.g., microcarriers, sensors, machine learning models etc). It is intended to be a collection of content that covers stem cell manufacturing from laboratory to industrial scale, including scale up or scale out systems, as well as representative scale down models for process development.

Topics of interest for this Special Issue include, but are not limited to:

• Stem cell bioprocesses for cultivated meat production
• Stem cell bioprocesses for cultivated leather production
• Stem cell bioprocesses for production of extracellular vesicles
• Stem cell bioprocesses for biotherapeutics
• Novel microcarriers (g. biodegradable, edible, dissolvable, liquid, temporary, stimuli responsive etc)
• Bioprocesses for stem cell differentiation
• Scale up / scale out / scale down models for stem cell bioprocessing
• Strategies for achieving cost effectiveness in stem cell bioprocesses
• Cost of goods analysis of stem cell bioprocesses
• Life cycle analysis of stem cell bioprocesses
• Application of machine learning and artificial intelligence in bioprocessing of stem cells
• Reviews of the current advances and challenges in stem cell bioprocessing for specific applications

Dr. Mariana Petronela Hanga
Dr. Eirini Theodosiou
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• bioprocessing of stem cells
• microcarriers
• biomaterials
• stem cell therapy
• cultivated meat
• ATMPs
• extracellular vesicles