Role of Hyaluronan in Human Health and Disease

Dear Colleagues,

Hyaluronan (HA) is a large carbohydrate polymer that is ubiquitously distributed in mammalian tissues. Its abundance, distribution and size are controlled by proteins and/or mechanical forces that regulate these parameters to allow for normal development and the maintenance of healthy tissues. HA synthesis-related proteins, hyaluronidases and HA-binding proteins are among the critical molecules known to be associated with alterations in HA that drive abnormal development and/or disease.

This Special issue will examine diseases and developmental abnormalities that are the consequences of the disruption of HA homeostasis and the mechanisms that underly these processes. Examples of these diseases include genetic disorders involving components of HA metabolism, cancers, fibrosis-related diseases, disorders of immune function and failures in normal tissue repair/regeneration.

Dr. Barbara Triggs-Raine
Dr. Soma Meran
Guest Editors

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• hyaluronan
• hyaluronidases
• hyaluronan-binding proteins
• hyaluronan receptors
• fibrosis
• cancer
• development
• immune function