Genetic and Epigenetic Insights into Extracellular Vesicles

Dear Colleagues,

Extracellular vesicles (EVs) are small membrane-bound vesicles that are secreted by various cells, including endocrine cells. They play crucial roles in intercellular communication by transferring various bioactive molecules, such as proteins, nucleic acids, and lipids, between cells. EVs carry genetic and epigenetic information, which may impact multiple cell functions and contribute to the regulation of homeostasis and a repertoire of signaling pathways. From genetic and epigenetic perspectives, EVs contain genetic material, including DNA, mRNAs, lncRNAs, microRNAs, and, possibly, other types of RNAs, transferring information horizontally among cells, organs, and tissues. On the other hand, EVs may be involved in epigenetic modifications, such as nucleic acid methylation, histone acetylation, etc.; play crucial roles in gene regulation; and be inherited vertically along consecutive generations. Thus, exosomal cargo may influence both the genetic and epigenetic landscapes of recipient cells and modulate many functions of proximal or distal tissues. In addition, given their presence in maternal milk, they may transfer information from mother to infant. Overall, the genetic, epigenetic, and other information carried by EVs are expected to provide insights into their roles in intercellular communication, as well as in gene regulation and in homeostasis in health and disease.

Prof. Dr. Dimitrios Vlachakis
Prof. Dr. George P. Chrousos
Guest Editors

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• exosomes
• extracellular vesicles
• cell–cell communication
• endocrinology