Antibiotics

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Special Issue Editors

Special Issue Information

Dear Colleagues,

The first volume of this Special Issue, “Antibiotic Residues, Antimicrobial Resistance and Intervention Strategies of Foodborne Pathogens”, was published in March 2023. It was a successful Special Issue, with 16 published papers, and has encouraged us to open a second volume on the same topic.

This Special Issue will celebrate World Antimicrobial Resistance Week (November 18~24), set up bythe FAO/UNEP/WAHO/WHO with a Tertiary Party Joint Action Plan for One Health, and brings together a diverse collection of articles from experts across various disciplines, including microbiology, pharmacy, epidemiology, and environtology. The topics of interest include, but are not limited to, the following:

Antibiotic residues;
Antibiotic resistance genes;
Antimicrobial resistance;
Food safety;
Foodborne pathogen;
Intervention strategies;
One Health.

Prof. Dr. Yongning Wu
Prof. Dr. Zhenling Zeng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Related Special Issue

Published Papers (1 paper)

Other

9 pages, 1459 KiB

Open AccessBrief Report

Characterization of Salmonella Phage P1-CTX and the Potential Mechanism Underlying the Acquisition of the bla_CTX-M-27 Gene

by Qiu-Yun Zhao, Run-Mao Cai, Ping Cai, Lin Zhang, Hong-Xia Jiang and Zhen-Ling Zeng

Antibiotics 2024, 13(5), 446; https://doi.org/10.3390/antibiotics13050446 - 14 May 2024

Viewed by 472

Abstract

The P1 phage has garnered attention as a carrier of antibiotic resistance genes (ARGs) in Enterobacteriaceae. However, the transferability of ARGs by P1-like phages carrying ARGs, in addition to the mechanism underlying ARG acquisition, remain largely unknown. In this study, we elucidated the biological characteristics, the induction and transmission abilities, and the acquisition mechanism of the bla_CTX-M-27 gene in the P1 phage. The P1-CTX phage exhibited distinct lytic plaques and possessed a complete head and tail structure. Additionally, the P1-CTX phage was induced successfully under various conditions, including UV exposure, heat treatment at 42 °C, and subinhibitory concentrations (sub-MICs) of antibiotics. Moreover, the P1-CTX phage could mobilize the bla_CTX-M-27 gene into three strains of Escherichia coli (E. coli) and the following seven different serotypes of Salmonella: Rissen, Derby, Kentucky, Typhimurium, Cerro, Senftenberg, and Muenster. The mechanism underlying ARG acquisition by the P1-CTX phage involved Tn1721 transposition-mediated movement of bla_CTX-M-27 into the ref and mat genes within its genome. To our knowledge, this is the first report documenting the dynamic processes of ARG acquisition by a phage. Furthermore, this study enriches the research on the mechanism underlying the phage acquisition of drug resistance genes and provides a basis for determining the risk of drug resistance during phage transmission. Full article

(This article belongs to the Special Issue Antibiotic Residues, Antimicrobial Resistance and Intervention Strategies of Foodborne Pathogens, 2nd Edition)

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