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Applied Sciences
Special Issues
Biological Activity and Applications of Natural Plant Compounds
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Biological Activity and Applications of Natural Plant Compounds

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1197

Special Issue Editors

Dr. Melania Florina Munteanu

E-Mail Website
Guest Editor
Department of Pharmaceutical Science, Faculty of Pharmacy, “Vasile Goldis” Western University of Arad, 86 Liviu Rebreanu Street, 310045 Arad, Romania
Interests: natural products; quercetin; supplements; biochemistry; functional foods; environmental chemistry
Dr. Elena Moroșan

E-Mail Website
Guest Editor
Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania
Interests: antioxidant action; hydroalcoholic plant extracts; oxidative stress; polyphenols; medical nutrition; phytochemicals

Special Issue Information

Dear Colleagues,

Plants are a huge source of chemical compounds. Flavonoids, anthocyanins, tannins, and carotenoids represent some of the better known natural compounds.

The biological activity of natural plant compounds is expressed through their actions on the human body. Among the most important effects, we list antioxidant, anti-inflammatory, antimicrobial, antitumor, immunomodulatory, neuroprotective, antihypertensive and antidiabetic activity.

This Special Issue of Applied Sciences entitled “Biological Activity and Applications of Natural Plant Compounds” highlights the importance of the activity of natural plant compounds and the diversity of their pharmacological activities.

Dr. Melania Florina Munteanu
Dr. Elena Moroșan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plants
  • compounds
  • biological activity
  • antioxidant
  • anti-inflammatory
  • antimicrobial
  • antitumor
  • immunomodulatory
  • neuroprotective
  • antihypertensive and antidiabetic activity
  • flavonoids
  • anthocyanins
  • tannins
  • carotenoids

Published Papers (2 papers)

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Research

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13 pages, 12571 KiB  
Article
Protective Effects of Hesperetin on Cardiomyocyte Integrity and Cytoskeletal Stability in a Murine Model of Epirubicin-Induced Cardiotoxicity: A Histopathological Study
by Adina Pop Moldovan, Simona Dumitra, Cristina Popescu, Radu Lala, Nicoleta Zurbau Anghel, Daniel Nisulescu, Ariana Nicoras, Coralia Cotoraci, Monica Puticiu, Anca Hermenean and Daniela Teodora Marti
Appl. Sci. 2024, 14(6), 2560; https://doi.org/10.3390/app14062560 - 19 Mar 2024
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Abstract
Anthracyclines, including epirubicin (Epi), are effective chemotherapeutics but are known for their cardiotoxic side effects, primarily inducing cardiomyocyte apoptosis. This study investigates the protective role of hesperetin (HSP) against cardiomyopathy triggered by Epi in a murine model. Male CD1 mice were divided into [...] Read more.
Anthracyclines, including epirubicin (Epi), are effective chemotherapeutics but are known for their cardiotoxic side effects, primarily inducing cardiomyocyte apoptosis. This study investigates the protective role of hesperetin (HSP) against cardiomyopathy triggered by Epi in a murine model. Male CD1 mice were divided into four groups, with the Epi group receiving a cumulative dose of 12 mg/kg intraperitoneally, reflecting a clinically relevant dosage. The co-treatment group received 100 mg/kg of HSP daily for 13 days. After the treatment period, mice were euthanized, and heart tissues were collected for histopathological, immunofluorescence/immunohistochemistry, and transmission electron microscopy (TEM) analyses. Histologically, Epi treatment led to cytoplasmic vacuolization, myofibril loss, and fiber disarray, while co-treatment with HSP preserved cardiac structure. Immunofluorescent analysis of Bcl-2 family proteins revealed Epi-induced upregulation of the pro-apoptotic protein Bax and a decrease in anti-apoptotic Bcl-2, which HSP treatment reversed. TEM observations confirmed the preservation of mitochondrial ultrastructure with HSP treatment. Moreover, in situ detection of DNA fragmentation highlighted a decrease in apoptotic nuclei with HSP treatment. In conclusion, HSP demonstrates a protective effect against Epi-induced cardiac injury and apoptosis, suggesting its potential as an adjunctive therapy in anthracycline-induced cardiomyopathy. Further studies, including chronic cardiotoxicity models and clinical trials, are warranted to optimize its therapeutic application in Epi-related cardiac dysfunction. Full article
(This article belongs to the Special Issue Biological Activity and Applications of Natural Plant Compounds)
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Review

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44 pages, 3434 KiB  
Review
Resveratrol: A Review on the Biological Activity and Applications
by Ludovic Everard Bejenaru, Andrei Biţă, Ionela Belu, Adina-Elena Segneanu, Antonia Radu, Andrei Dumitru, Maria Viorica Ciocîlteu, George Dan Mogoşanu and Cornelia Bejenaru
Appl. Sci. 2024, 14(11), 4534; https://doi.org/10.3390/app14114534 - 25 May 2024
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Abstract
Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible [...] Read more.
Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine. Full article
(This article belongs to the Special Issue Biological Activity and Applications of Natural Plant Compounds)
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