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Bioengineering
Special Issues
Peptide-Based Vaccines: An Efficient Alternative to Combat Infectious Diseases and...
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Peptide-Based Vaccines: An Efficient Alternative to Combat Infectious Diseases and Drug Resistance

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 851

Special Issue Editors

Dr. Piyush Baindara

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Guest Editor
Animal Sciences Research Center, University of Missouri, Columbia, MO 65211, USA
Interests: antimicrobial peptides; infectious diseases; vaccines; anticancer; drug resistance
Dr. Ravinder Kumar

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Guest Editor
Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Interests: yeast-based vaccine; virus like particles; yeast-based screening; industrial application of yeast; recombinant proteins
Dr. Santi Mandal

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Guest Editor
Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India
Interests: antimicrobial peptides; drug resistance; protein engineering; lipopeptides

Special Issue Information

Dear Colleagues,

As the world is already struggling with the rapid emergence of drug resistance and scarcity of efficient antibiotics, the outbreak of new infectious agents such as SARS-CoV-2 has made the development of new antimicrobial agent or strategies to fight against these challenges urgent. Peptide-based vaccines are recognized as one such potential strategy for combatting drug resistance and new infections. Vaccines have already been proven to improve the management of infectious diseases as they aim to prevent infectious disease rather than treat it. Further, the use of antimicrobial peptides (AMPs) as subunit vaccines or adjuvants is another potential strategy with which to combat infections and thus slow down the evolution of drug resistance.

For this Special Issue, authors are invited to submit original research, review articles, short communications, case series, and opinion papers related to but not limited to the following specific topics of interest:

  1. Characterization and design of novel-peptide-based vaccines or therapies.
  2. Strategies for the development of peptide-based vaccines against infectious diseases.
  3. Peptide-based vaccines and immunotherapies to combat cancer.
  4. Applications and strategies to use peptide-based vaccines against autoimmune disease.
  5. Peptide-based vaccines to combat against fungal infections and antifungal drug resistance.
  6. Protein engineering strategies to design and alter the pattern of immunodominance in peptide-based vaccines.
  7. Combination treatment strategies of peptide-based vaccines with other drugs or therapies to improve efficacy.

Peptide-based immunotherapies in clinical trials and therapeutics.

Dr. Piyush Baindara
Dr. Ravinder Kumar
Dr. Santi Mohan Mandal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • peptide-based vaccines
  • drug resistance
  • protein engineering
  • infectious diseases
  • antibacterial
  • antifungal
  • antiviral
  • immunotherapies
  • therapeutics

Published Papers (1 paper)

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Research

24 pages, 7165 KiB  
Article
Subtractive Proteomics and Reverse-Vaccinology Approaches for Novel Drug Target Identification and Chimeric Vaccine Development against Bartonella henselae Strain Houston-1
by Sudais Rahman, Chien-Chun Chiou, Shabir Ahmad, Zia Ul Islam, Tetsuya Tanaka, Abdulaziz Alouffi, Chien-Chin Chen, Mashal M. Almutairi and Abid Ali
Bioengineering 2024, 11(5), 505; https://doi.org/10.3390/bioengineering11050505 - 17 May 2024
Viewed by 585
Abstract
Bartonella henselae is a Gram-negative bacterium causing a variety of clinical symptoms, ranging from cat-scratch disease to severe systemic infections, and it is primarily transmitted by infected fleas. Its status as an emerging zoonotic pathogen and its capacity to persist within host erythrocytes [...] Read more.
Bartonella henselae is a Gram-negative bacterium causing a variety of clinical symptoms, ranging from cat-scratch disease to severe systemic infections, and it is primarily transmitted by infected fleas. Its status as an emerging zoonotic pathogen and its capacity to persist within host erythrocytes and endothelial cells emphasize its clinical significance. Despite progress in understanding its pathogenesis, limited knowledge exists about the virulence factors and regulatory mechanisms specific to the B. henselae strain Houston-1. Exploring these aspects is crucial for targeted therapeutic strategies against this versatile pathogen. Using reverse-vaccinology-based subtractive proteomics, this research aimed to identify the most antigenic proteins for formulating a multi-epitope vaccine against the B. henselae strain Houston-1. One crucial virulent and antigenic protein, the PAS domain-containing sensor histidine kinase protein, was identified. Subsequently, the identification of B-cell and T-cell epitopes for the specified protein was carried out and the evaluated epitopes were checked for their antigenicity, allergenicity, solubility, MHC binding capability, and toxicity. The filtered epitopes were merged using linkers and an adjuvant to create a multi-epitope vaccine construct. The structure was then refined, with 92.3% of amino acids falling within the allowed regions. Docking of the human receptor (TLR4) with the vaccine construct was performed and demonstrated a binding energy of −1047.2 Kcal/mol with more interactions. Molecular dynamic simulations confirmed the stability of this docked complex, emphasizing the conformation and interactions between the molecules. Further experimental validation is necessary to evaluate its effectiveness against B. henselae. Full article
(This article belongs to the Special Issue Peptide-Based Vaccines: An Efficient Alternative to Combat Infectious Diseases and Drug Resistance)
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