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Cancers
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Current Clinical Studies of Pancreatic Ductal Adenocarcinoma
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Current Clinical Studies of Pancreatic Ductal Adenocarcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 1692

Special Issue Editor

Dr. Govindarajan Narayanan

E-Mail Website
Guest Editor
1. Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA
2. Miami Cardiac and Vascular, Baptist Health South Florida, Miami, FL 33176, USA
3. Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
Interests: HCC; pancreas cancer; cancer ablation; IRE; mCRC
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to annnounce the launch of a Special Issue on ‘Current Clinical Studies of Pancreatic Ductal Adenocarcinoma’ which will take the form of a multi-disciplinary project, incoporating research on medical oncology, current trends in neoadjuvant and adjuvant chemotherapy for pancreatic cancer, and surgical managements such as open and minimally invasive techniques. This Special Issue will also highlight studies on the locoregional treatment space including advances in SBRT and MR-guided Linac along with irreversible electroporation (IRE) using an open surgical approach and a percutaneous approach. Additionally, bench research analyzing the role of local treatment in enhancing immune response and/or the impact of local treatment on the stromal tissue of pancreatic cancer, which improves the uptake of immunotherapy, will also be incorporated.

Dr. Govindarajan Narayanan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Review

25 pages, 9517 KiB  
Review
Controversies in Endoscopic Ultrasound-Guided Biliary Drainage
by Christoph Frank Dietrich, Paolo Giorgio Arcidiacono, Manoop S. Bhutani, Barbara Braden, Eike Burmester, Pietro Fusaroli, Michael Hocke, Andrè Ignee, Christian Jenssen, Abed Al-Lehibi, Emad Aljahdli, Bertrand Napoléon, Mihai Rimbas and Giuseppe Vanella
Cancers 2024, 16(9), 1616; https://doi.org/10.3390/cancers16091616 - 23 Apr 2024
Viewed by 442
Abstract
In this 14th document in a series of papers entitled “Controversies in Endoscopic Ultrasound” we discuss various aspects of EUS-guided biliary drainage that are debated in the literature and in practice. Endoscopic retrograde cholangiography is still the reference technique for therapeutic [...] Read more.
In this 14th document in a series of papers entitled “Controversies in Endoscopic Ultrasound” we discuss various aspects of EUS-guided biliary drainage that are debated in the literature and in practice. Endoscopic retrograde cholangiography is still the reference technique for therapeutic biliary access, but EUS-guided techniques for biliary access and drainage have developed into safe and highly effective alternative options. However, EUS-guided biliary drainage techniques are technically demanding procedures for which few training models are currently available. Different access routes require modifications to the basic technique and specific instruments. In experienced hands, percutaneous transhepatic cholangiodrainage is also a good alternative. Therefore, in this paper, we compare arguments for different options of biliary drainage and different technical modifications. Full article
(This article belongs to the Special Issue Current Clinical Studies of Pancreatic Ductal Adenocarcinoma)
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14 pages, 991 KiB  
Review
Involvement of the Gut Microbiome in the Local and Systemic Immune Response to Pancreatic Ductal Adenocarcinoma
by James M. Halle-Smith, Hayden Pearce, Samantha Nicol, Lewis A. Hall, Sarah F. Powell-Brett, Andrew D. Beggs, Tariq Iqbal, Paul Moss and Keith J. Roberts
Cancers 2024, 16(5), 996; https://doi.org/10.3390/cancers16050996 - 29 Feb 2024
Viewed by 906
Abstract
The systemic and local immunosuppression exhibited by pancreatic ductal adenocarcinoma (PDAC) contributes significantly to its aggressive nature. There is a need for a greater understanding of the mechanisms behind this profound immune evasion, which makes it one of the most challenging malignancies to [...] Read more.
The systemic and local immunosuppression exhibited by pancreatic ductal adenocarcinoma (PDAC) contributes significantly to its aggressive nature. There is a need for a greater understanding of the mechanisms behind this profound immune evasion, which makes it one of the most challenging malignancies to treat and thus one of the leading causes of cancer death worldwide. The gut microbiome is now thought to be the largest immune organ in the body and has been shown to play an important role in multiple immune-mediated diseases. By summarizing the current literature, this review examines the mechanisms by which the gut microbiome may modulate the immune response to PDAC. Evidence suggests that the gut microbiome can alter immune cell populations both in the peripheral blood and within the tumour itself in PDAC patients. In addition, evidence suggests that the gut microbiome influences the composition of the PDAC tumour microbiome, which exerts a local effect on PDAC tumour immune infiltration. Put together, this promotes the gut microbiome as a promising route for future therapies to improve immune responses in PDAC patients. Full article
(This article belongs to the Special Issue Current Clinical Studies of Pancreatic Ductal Adenocarcinoma)
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