Regulatory Programs of Skeletal Muscle Repair and Regeneration
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 May 2024 | Viewed by 1773
Special Issue Editors
Interests: anatomy, skeletal muscle tissue repair and regeneration; fibrosis; regenerative medicine; stromal cells; photobiomodulation, platelet rich plasma
Interests: skeletal muscle, smooth muscle, gap junctions, myotubes, ion channels, electrophysiology, adipokines, stem cells, excitation contraction coupling, damage, bioactive lipids, muscle atrophy, neurons
Special Issue Information
Dear Colleagues,
Adult healthy skeletal muscle possesses a robust capability to repair/regenerate. This is mediated by its resident stem cells, called satellite cells (SCs) on account of their position at the periphery of the host myofiber. SC behavior is finely regulated by both intrinsic (pre-programmed signaling pathways, telomerase functionality, epigenetic adaptive changes) and extrinsic mechanisms (mutual paracrine/juxtacrine interactions that SCs establish with niche, mechanical stimuli). Stromal interstitial cells are emerging as integral to an efficient muscle repair/regeneration. Usually, upon a focal damage, an adaptive reparative fibrotic (transient) response occurs, compliant with SC proper functionality, sustaining their progression into the myogenic program and the morpho-functional recovery of injured muscle. Conversely, in severely/persistently damaged or pathological muscles, the niche conveys instructive signals, skewing the fate of unhealthy muscles toward fibro-adipogenic degeneration that is not conducive for SC functionality, often already compromised in these conditions. Despite the recent advances, some aspects of this inherent muscle program are unclear. Thus, renewed efforts are required to provide novel mechanistic insights into the complex network orchestrating SC activity and into degeneration/regeneration (un)balance. This Special Issue welcomes studies that will improve the current knowledge on this fascinating topic and that may certainly offer cues for smart therapeutic target identification.
Prof. Dr. Chiara Sassoli
Prof. Dr. Roberta Squecco
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
