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Cells
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MicroRNA as Biomarker in Carcinoma Cell
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MicroRNA as Biomarker in Carcinoma Cell

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2770

Special Issue Editors

Dr. Carlos Pérez Plasencia

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Guest Editor
Laboratorio de Genómica, Unidad de Biomedicina, Facultad de Estudios Superiores, Instituto Nacional de Cancerologia, Mexico City 14080, Mexico
Interests: miRNA; ncRNA; cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. César López-Camarillo

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Guest Editor
Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico City 03100, Mexico
Interests: cell signaling; protein expression; cell biology; genetics; cell culture; cancer biology
Special Issues, Collections and Topics in MDPI journals
Dr. Eduardo López-Urrutia

E-Mail Website
Guest Editor
Laboratorio de Genómica, Unidad de Biomedicina, FES-IZTACALA, UNAM, Tlalnepantla 54090, Mexico
Interests: RNA; cancer; molecular biology

Special Issue Information

Dear Colleagues,

Carcinoma, a type of cancer originating from epithelial cells, represents a significant global health concern, with approximately 80–90% of cancer diagnoses resulting from carcinoma. Carcinoma is a highly heterogeneous and complex disease characterized by uncontrolled cell proliferation, invasion, and metastasis. Conventional methods for carcinoma diagnosis and monitoring, such as imaging techniques and tissue biopsies, often have limitations in terms of invasiveness, cost, and sample availability. Therefore, the identification of reliable and non-invasive biomarkers is crucial for early detection, accurate prognosis, and personalized therapeutic interventions.

Early detection and accurate monitoring of carcinoma are critical for effective treatment and improved patient outcomes. In recent years, microRNAs (miRNAs) have emerged as promising biomarkers due to their essential roles in gene regulation and their stability in various biological samples. MicroRNAs show great potential as diagnostic biomarkers in carcinoma. Their differential expression patterns between carcinoma tissues and healthy controls have been extensively studied. Several studies have reported specific microRNA signatures associated with different carcinoma types, allowing for accurate discrimination between malignant and benign lesions. Moreover, microRNAs can be detected in various body fluids, such as blood, urine, and saliva, offering non-invasive and easily accessible samples for diagnostic purposes. This Special Issue aims to highlight the importance of microRNAs as biomarkers in carcinoma cells, focusing on their potential applications in diagnosis, prognosis, and therapeutic response monitoring. Original and review manuscripts containing relevant information regarding carcinoma and any innovative miRNA research, including the study of microRNA functionality via both biological and computational methods, clinical studies addressing miRNA biomarkers and miRNA, researching exploring the role of microRNAs in carcinoma pathogenesis, etc., are welcome.

Dr. Carlos Pérez Plasencia
Prof. Dr. César López-Camarillo
Dr. Eduardo López-Urrutia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carcinoma cell
  • microRNA
  • prognosis
  • diagnoses
  • molecular biomarker
  • methods for detection
  • miRNA targets

Published Papers (2 papers)

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Research

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15 pages, 6127 KiB  
Article
A microRNA Profile Regulates Inflammation-Related Signaling Pathways in Young Women with Locally Advanced Cervical Cancer
by Oliver Millan-Catalan, Eloy Andrés Pérez-Yépez, Antonio Daniel Martínez-Gutiérrez, Miguel Rodríguez-Morales, Eduardo López-Urrutia, Jaime Coronel-Martínez, David Cantú de León, Nadia Jacobo-Herrera, Oscar Peralta-Zaragoza, César López-Camarillo, Mauricio Rodríguez-Dorantes and Carlos Pérez-Plasencia
Cells 2024, 13(11), 896; https://doi.org/10.3390/cells13110896 - 23 May 2024
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Abstract
Cervical cancer (CC) remains among the most frequent cancers worldwide despite advances in screening and the development of vaccines against human papillomavirus (HPV), involved in virtually all cases of CC. In mid-income countries, a substantial proportion of the cases are diagnosed in advanced [...] Read more.
Cervical cancer (CC) remains among the most frequent cancers worldwide despite advances in screening and the development of vaccines against human papillomavirus (HPV), involved in virtually all cases of CC. In mid-income countries, a substantial proportion of the cases are diagnosed in advanced stages, and around 40% of them are diagnosed in women under 49 years, just below the global median age. This suggests that members of this age group share common risk factors, such as chronic inflammation. In this work, we studied samples from 46 patients below 45 years old, searching for a miRNA profile regulating cancer pathways. We found 615 differentially expressed miRNAs between tumor samples and healthy tissues. Through bioinformatic analysis, we found that several of them targeted elements of the JAK/STAT pathway and other inflammation-related pathways. We validated the interactions of miR-30a and miR-34c with JAK1 and STAT3, respectively, through dual-luciferase and expression assays in cervical carcinoma-derived cell lines. Finally, through knockdown experiments, we observed that these miRNAs decreased viability and promoted proliferation in HeLa cells. This work contributes to understanding the mechanisms through which HPV regulates inflammation, in addition to its canonical oncogenic function, and brings attention to the JAK/STAT signaling pathway as a possible diagnostic marker for CC patients younger than 45 years. To our knowledge to date, there has been no previous description of a panel of miRNAs or even ncRNAs in young women with locally advanced cervical cancer. Full article
(This article belongs to the Special Issue MicroRNA as Biomarker in Carcinoma Cell)
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Review

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0 pages, 2222 KiB  
Review
miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities
by Wilson Huang, Doru Paul, George A. Calin and Recep Bayraktar
Cells 2024, 13(1), 84; https://doi.org/10.3390/cells13010084 - 30 Dec 2023
Cited by 1 | Viewed by 2101
Abstract
MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological targets, has been the subject of countless [...] Read more.
MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological targets, has been the subject of countless studies over the years. Due to its preferential expression in hematopoietic cells, miR-142 has been found to be associated with numerous types of lymphomas and leukemias. This review elucidates the multifaceted role of miR-142 in human physiology, its influence on hematopoiesis and hematopoietic cells, and its intriguing involvement in exosome-mediated miR-142 transport. Moreover, we offer a comprehensive exploration of the genetic and molecular landscape of the miR-142 genomic locus, highlighting its mutations and dysregulation within hematological malignancies. Finally, we discuss potential avenues for harnessing the therapeutic potential of miR-142 in the context of hematological malignancies. Full article
(This article belongs to the Special Issue MicroRNA as Biomarker in Carcinoma Cell)
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