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Molecular Mechanisms of HPV-Induced Carcinogenesis
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Molecular Mechanisms of HPV-Induced Carcinogenesis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 463

Special Issue Editor

Dr. Ana Gradissimo

E-Mail Website
Guest Editor
Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Interests: next-generation sequencing; microbial assays; viral tumorigenesis; human papillomavirus (HPV); cervical carcinogenesis

Special Issue Information

Dear Colleagues,

Human papillomavirus (HPV) infections remain common among women globally despite the high effectiveness of both screening and prophylactic vaccination programs. Honoring the World Health Organization (WHO) action plan towards cervical cancer elimination by 2030, strategies combining extended vaccination coverage to more vulnerable populations with HPV-based screening programs are being expanded. Yet, there are research avenues that warrant scientific investigations. A deeper dive into the viral mechanisms leading to carcinogenesis can have an immediate significant impact on establishing clinical interventions to prevent HPV-induced cancer development after the onset of a persistent HPV infection. One particular area of clinical interest is the differentiation between squamous cell carcinoma and adenocarcinoma; the latter shows an increase in incidence and faster disease progression, while gaps in knowledge are slowly being filled. High-risk papillomaviruses share in their biology the secrets to cancer development. Defining key molecular events occurring within HPV and its host is fundamental in resolving HPV infections leading to high-grade malignancies beyond cervical cancer. Growing our understanding of molecular mechanisms such as (i) viral integration, (ii) oncoprotein expression, (iii) host genomic instability, (iv) microbiome, (v) or cell cycle changes is key to better comprehending how these viruses play an active role in cancer development.

This Special Issue focuses on the biology of papillomaviruses and their oncogenic potential in developing cancer in humans. Original research articles, short communications, and reviews are all welcome for submission to this Special Issue.

Dr. Ana Gradissimo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human papillomavirus
  • cervical cancer
  • adenocarcinoma
  • carcinogenesis
  • viral integration
  • microbiome
  • genomic instability
  • next-generation sequencing
  • new methodologies
  • viral biomarkers
  • molecular signatures

Published Papers (1 paper)

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10 pages, 1983 KiB  
Brief Report
Proof of Concept Study: Comparability of Microbiome Diversity in Self- and Physician-Collected HPV-Positive and HPV-Negative Cervicovaginal Samples
by Laura Asensio-Puig, Álvaro de Andrés-Pablo, Olfat Khannous-Lleiffe, Raquel Ibáñez, Amelia Acera, Silvia de Sanjosé, Toni Gabaldón, Laia Alemany, Laia Bruni and Miquel Àngel Pavón
Int. J. Mol. Sci. 2024, 25(11), 5736; https://doi.org/10.3390/ijms25115736 - 24 May 2024
Viewed by 221
Abstract
Recent studies have revealed the impact of human papillomavirus (HPV) infections on the cervicovaginal microbiome; however, few have explored the utility of self-collected specimens (SCS) for microbiome detection, obtained using standardised methods for HPV testing. Here, we present a proof-of-concept analysis utilising Oxford [...] Read more.
Recent studies have revealed the impact of human papillomavirus (HPV) infections on the cervicovaginal microbiome; however, few have explored the utility of self-collected specimens (SCS) for microbiome detection, obtained using standardised methods for HPV testing. Here, we present a proof-of-concept analysis utilising Oxford Nanopore sequencing of the 16S rRNA gene in paired samples collected either by the patient using an Evalyn Brush or collected by a physician using liquid-based cytology (LBC). We found no significant differences in the α-diversity estimates between the SCS and LBC samples. Similarly, when analysing β-diversity, we observed a close grouping of paired samples, indicating that both collection methods detected the same microbiome features. The identification of genera and Lactobacillus species in each sample allowed for their classification into community state types (CSTs). Notably, paired samples had the same CST, while HPV-positive and -negative samples belonged to distinct CSTs. As previously described in other studies, HPV-positive samples exhibited heightened bacterial diversity, reduced Lactobacillus abundance, and an increase in genera like Sneathia or Dialister. Altogether, this study showed comparable results between the SCS and LBC samples, underscoring the potential of self-sampling for analysing the microbiome composition in cervicovaginal samples initially collected for HPV testing in the context of cervical cancer screening. Full article
(This article belongs to the Special Issue Molecular Mechanisms of HPV-Induced Carcinogenesis)
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