International Journal of Molecular Sciences

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Special Issue Editor

Dr. Young Bok Lee

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Guest Editor

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
Interests: acne; actinic keratosis; atopic dermatitis; Behcet’s disease; bullous pemphigoid; hidradenitis suppurativa; rosacea; skin cancer; pemphigus; psoriasis; urticaria

Special Issue Information

Dear Colleagues,

As advances in science and technology have progressed, we have gained a deeper understanding of skin diseases. Recent developments in the field of dermatology have produced new medications and biologics for conditions like psoriasis, atopic dermatitis, and hidradenitis suppurativa, thereby accelerating research in the field of dermatology. Therefore, there is a growing need to systematically compile the latest insights into the pathophysiological mechanisms of and treatment strategies for skin diseases.

In this vein, we invite submissions to this Special Issue under the title 'Latest Advances on Skin Disease: Pathophysiological Mechanisms and Treatment Strategies'. We encourage authors to contribute research papers that highlight advancements in the etiology of and treatment approaches to various skin conditions.

Dr. Young Bok Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

acne
actinic keratosis
atopic dermatitis
Behcet’s disease
bullous pemphigoid
hidradenitis suppurativa
rosacea
skin cancer
pemphigus
psoriasis
urticaria

Published Papers (2 papers)

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Research

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14 pages, 3904 KiB

Open AccessArticle

Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes

by Stefano Piazza, Giulia Martinelli, Nicole Maranta, Carola Pozzoli, Marco Fumagalli, Vincenzo Nicolaci, Elisa Sonzogni, Luca Colombo, Enrico Sangiovanni and Mario Dell’Agli

Int. J. Mol. Sci. 2024, 25(9), 4764; https://doi.org/10.3390/ijms25094764 - 27 Apr 2024

Viewed by 606

Abstract

Acne vulgaris is a prevalent skin disorder affecting many young individuals, marked by keratinization, inflammation, seborrhea, and colonization by Cutibacterium acnes (C. acnes). Ellagitannins, known for their antibacterial and anti-inflammatory properties, have not been widely studied for their anti-acne effects. Chestnut (Castanea sativa Mill., C. sativa), a rich ellagitannin source, including castalagin whose acne-related bioactivity was previously unexplored, was investigated in this study. The research assessed the effect of C. sativa leaf extract and castalagin on human keratinocytes (HaCaT) infected with C. acnes, finding that both inhibited IL-8 and IL-6 release at concentrations below 25 μg/mL. The action mechanism was linked to NF-κB inhibition, without AP-1 involvement. Furthermore, the extract displayed anti-biofilm properties and reduced CK-10 expression, indicating a potential role in mitigating inflammation, bacterial colonization, and keratosis. Castalagin’s bioactivity mirrored the extract’s effects, notably in IL-8 inhibition, NF-κB inhibition, and biofilm formation at low μM levels. Other polyphenols, such as flavonol glycosides identified via LC-MS, might also contribute to the extract’s biological activities. This study is the first to explore ellagitannins’ potential in treating acne, offering insights for developing chestnut-based anti-acne treatments pending future in vivo studies. Full article

(This article belongs to the Special Issue Latest Advances in Skin Disease: Pathophysiological Mechanisms and Treatment Strategies)

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Review

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34 pages, 1376 KiB

Open AccessReview

Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies

by Hyun Jee Kim and Yeong Ho Kim

Int. J. Mol. Sci. 2024, 25(10), 5302; https://doi.org/10.3390/ijms25105302 - 13 May 2024

Viewed by 399

Abstract

Acne vulgaris is a common dermatological condition that can present across different ages but predominantly affects adolescents and young adults. Characterized by various lesion types, the pathogenesis of acne is complex, involving genetic, hormonal, microbial, and inflammatory factors. This review comprehensively addresses current and emerging acne management strategies, emphasizing both topical and systemic treatments, procedural therapies, and dietary modifications. Key topical agents include retinoids, benzoyl peroxide, antibiotics, and other specialized compounds. Systemic options like antibiotics, hormonal therapies, and retinoids offer significant therapeutic benefits, particularly for moderate to severe cases. Procedural treatments such as laser devices, photodynamic therapy, chemical peels, and intralesional injections present viable alternatives for reducing acne symptoms and scarring. Emerging therapies focus on novel biologics, bacteriophages, probiotics, and peptides, providing promising future options. This review underscores the importance of personalized approaches to treatment due to the multifaceted nature of acne, highlighting the potential of innovative therapies for improving patient outcomes. Full article

(This article belongs to the Special Issue Latest Advances in Skin Disease: Pathophysiological Mechanisms and Treatment Strategies)

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