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Proteomics and Its Applications in Disease 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 723

Special Issue Editors


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Guest Editor
1. School of Optometry, Department of Applied Biology and Chemical Technology, Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong 999077, China
2. Singapore Eye Research Institute, The Academia, 20 College Road, Singapore 169856, Singapore
Interests: mass spectrometry; proteomics; metabolomics; disease biomarker
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore
Interests: proteomics; mass spectrometry; disease biomarker; drug target identification; aquaporin biomimetic membrane
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous successful Special Issue “Proteomics and Its Applications in Disease”.

Recent advances in mass spectrometry-based technologies, e.g., data-independent acquisition (DIA), ion mobility spectrometry (IMS), and multiple reaction monitoring (MRM), have provided superior sensitivity, reproducibility, and throughput in proteomics analysis. This allows researchers to explore diseases by assessing a deeper proteome in a relatively short time with high reproducibility and fewer missing data. No doubt, the applications of proteomics research in diseases not only provide new insights into disease mechanisms, but also novel disease biomarkers and therapeutic targets.

In this Special Issue, we invite you to contribute original research and review articles which focus on (but are not limited to) the following topics related to the applications of proteomics in diseases: disease biomarker (discovery and validation), molecular mechanisms (signaling pathway) of disease, new drug targets, the role of post-translational modifications in disease, targeted proteomics, multi-omics studies, proteomic studies on in vitro cell disease models, animal disease models, or patient cohort studies.

Prof. Dr. Lei Zhou
Dr. Qingsong Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • proteomics
  • quantitative proteomics
  • biomarkers
  • signaling pathways
  • post-translational modifications
  • disease mechanism
  • novel therapeutic targets

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Published Papers (1 paper)

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Research

21 pages, 2726 KiB  
Article
Altered Serum Proteins Suggest Inflammation, Fibrogenesis and Angiogenesis in Adult Patients with a Fontan Circulation
by Miriam Michel, David Renaud, Ronny Schmidt, Matthias Einkemmer, Lea Valesca Laser, Erik Michel, Karl Otto Dubowy, Daniela Karall, Kai Thorsten Laser and Sabine Scholl-Bürgi
Int. J. Mol. Sci. 2024, 25(10), 5416; https://doi.org/10.3390/ijms25105416 - 16 May 2024
Viewed by 523
Abstract
Previous omics research in patients with complex congenital heart disease and single-ventricle circulation (irrespective of the stage of palliative repair) revealed alterations in cardiac and systemic metabolism, inter alia abnormalities in energy metabolism, and inflammation, oxidative stress or endothelial dysfunction. We employed an [...] Read more.
Previous omics research in patients with complex congenital heart disease and single-ventricle circulation (irrespective of the stage of palliative repair) revealed alterations in cardiac and systemic metabolism, inter alia abnormalities in energy metabolism, and inflammation, oxidative stress or endothelial dysfunction. We employed an affinity-proteomics approach focused on cell surface markers, cytokines, and chemokines in the serum of 20 adult Fontan patients with a good functioning systemic left ventricle, and we 20 matched controls to reveal any specific processes on a cellular level. Analysis of 349 proteins revealed 4 altered protein levels related to chronic inflammation, with elevated levels of syndecan-1 and glycophorin-A, as well as decreased levels of leukemia inhibitory factor and nerve growth factor-ß in Fontan patients compared to controls. All in all, this means that Fontan circulation carries specific physiological and metabolic instabilities, including chronic inflammation, oxidative stress imbalance, and consequently, possible damage to cell structure and alterations in translational pathways. A combination of proteomics-based biomarkers and the traditional biomarkers (uric acid, γGT, and cholesterol) performed best in classification (patient vs. control). A metabolism- and signaling-based approach may be helpful for a better understanding of Fontan (patho-)physiology. Syndecan-1, glycophorin-A, leukemia inhibitory factor, and nerve growth factor-ß, especially in combination with uric acid, γGT, and cholesterol, might be interesting candidate parameters to complement traditional diagnostic imaging tools and the determination of traditional biomarkers, yielding a better understanding of the development of comorbidities in Fontan patients, and they may play a future role in the identification of targets to mitigate inflammation and comorbidities in Fontan patients. Full article
(This article belongs to the Special Issue Proteomics and Its Applications in Disease 3.0)
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