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Genetic Biology of Embryonic Development
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Genetic Biology of Embryonic Development

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 2285

Special Issue Editor

Dr. Adam Davis

E-Mail Website
Guest Editor
Department of Biology, University of North Georgia, Oakwood, GA 30566, USA
Interests: evolutionary and developmental biology; embryonic gene expression; vertebrate head development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Having a solid background on how genes pattern embryonic development is crucial for understanding the development of human disorders as well as the evolution of complex mechanisms that shape anatomical structures. Such mechanisms involve complex genetic regulatory networks; morphogenesis at the subcellular, cellular, and gross anatomical levels; and environmental interactions with the genome during embryonic development. This Special Issue of the International Journal of Molecular Sciences shall encompass articles on these mechanisms as well as others to help broaden our understanding of the genetic basis of embryonic development. Research manuscripts and comprehensive reviews adhering to the journal’s aims will be accepted.

Potential topics include, but are not limited to:

  • Mechanisms of gene regulation during embryogenesis
  • Differential gene expression at the levels of transcription, mRNA processing, translation, and protein modification
  • Genetic regulation of early developmental processes, including fertilization, cleavage, and gastrulation
  • Morphogenetic patterning mechanisms at subcellular, cellular and gross anatomical levels
  • Genetic causes of medical disorders
  • Genomic and environmental interactions on embryonic development
  • Divergence in genetic regulatory mechanisms among evolutionary divergent lineages
  • Evolution of divergent anatomical structures among evolutionary divergent lineages

Dr. Adam Davis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • embryonic development

  • evolution and development
  • genetic regulatory networks
  • gene expression and regulation
  • cellular and subcellular morphogenesis
  • anatomical patterning
  • genomic–environmental interactions
  • axis development
  • medical disorders
  • molecular genetics

Published Papers (2 papers)

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Research

17 pages, 24599 KiB  
Article
Histone Lactylation Is Involved in Mouse Oocyte Maturation and Embryo Development
by Diqi Yang, Haoyi Zheng, Wenjie Lu, Xueqi Tian, Yanyu Sun and Hui Peng
Int. J. Mol. Sci. 2024, 25(9), 4821; https://doi.org/10.3390/ijms25094821 - 28 Apr 2024
Viewed by 447
Abstract
Numerous post-translational modifications are involved in oocyte maturation and embryo development. Recently, lactylation has emerged as a novel epigenetic modification implicated in the regulation of diverse cellular processes. However, it remains unclear whether lactylation occurs during oocyte maturation and embryo development processes. Herein, [...] Read more.
Numerous post-translational modifications are involved in oocyte maturation and embryo development. Recently, lactylation has emerged as a novel epigenetic modification implicated in the regulation of diverse cellular processes. However, it remains unclear whether lactylation occurs during oocyte maturation and embryo development processes. Herein, the lysine lactylation (Kla) modifications were determined during mouse oocyte maturation and early embryo development by immunofluorescence staining. Exogenous lactate was supplemented to explore the consequences of modulating histone lactylation levels on oocyte maturation and embryo development processes by transcriptomics. Results demonstrated that lactylated proteins are widely present in mice with tissue- and cell-specific distribution. During mouse oocyte maturation, immunofluorescence for H3K9la, H3K14la, H4K8la, and H4K12la was most intense at the germinal vesicle (GV) stage and subsequently weakened or disappeared. Further, supplementing the culture medium with 10 mM sodium lactate elevated both the oocyte maturation rate and the histone Kla levels in GV oocytes, and there were substantial increases in Kla levels in metaphase II (MII) oocytes. It altered the transcription of molecules involved in oxidative phosphorylation. Moreover, histone lactylation levels changed dynamically during mouse early embryogenesis. Sodium lactate at 10 mM enhanced early embryo development and significantly increased lactylation, while impacting glycolytic gene transcription. This study reveals the roles of lactylation during oocyte maturation and embryo development, providing new insights to improving oocyte maturation and embryo quality. Full article
(This article belongs to the Special Issue Genetic Biology of Embryonic Development)
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17 pages, 5906 KiB  
Article
DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese
by Xumeng Zhang, Yong Li, Chenyu Zhu, Fada Li, Zhiyuan Liu, Xiujin Li, Xu Shen, Zhongping Wu, Mengsi Fu, Danning Xu, Yunbo Tian and Yunmao Huang
Int. J. Mol. Sci. 2023, 24(8), 7188; https://doi.org/10.3390/ijms24087188 - 13 Apr 2023
Cited by 4 | Viewed by 1241
Abstract
Skeletal muscle development from embryonic stages to hatching is critical for poultry muscle growth, during which DNA methylation plays a vital role. However, it is not yet clear how DNA methylation affects early embryonic muscle development between goose breeds of different body size. [...] Read more.
Skeletal muscle development from embryonic stages to hatching is critical for poultry muscle growth, during which DNA methylation plays a vital role. However, it is not yet clear how DNA methylation affects early embryonic muscle development between goose breeds of different body size. In this study, whole genome bisulfite sequencing (WGBS) was conducted on leg muscle tissue from Wuzong (WZE) and Shitou (STE) geese on embryonic day 15 (E15), E23, and post-hatch day 1. It was found that at E23, the embryonic leg muscle development of STE was more intense than that of WZE. A negative correlation was found between gene expression and DNA methylation around transcription start sites (TSSs), while a positive correlation was observed in the gene body near TTSs. It was also possible that earlier demethylation of myogenic genes around TSSs contributes to their earlier expression in WZE. Using pyrosequencing to analyze DNA methylation patterns of promoter regions, we also found that earlier demethylation of the MyoD1 promoter in WZE contributed to its earlier expression. This study reveals that DNA demethylation of myogenic genes may contribute to embryonic leg muscle development differences between Wuzong and Shitou geese. Full article
(This article belongs to the Special Issue Genetic Biology of Embryonic Development)
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