Life | Special Issue : Fertility Preservation in Female and Male Benign and Malignant Conditions: 2nd Edition

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Special Issue Information

Dear Colleagues,

The number of cancer survivors has continually increased in recent years, with cancer survival doubling in the last 40 years; this is particularly true for cancers that affect a younger population, such as testicular cancer, childhood lymphoblastic leukaemia, and Hodgkin’s lymphoma, as well as breast cancer. However, these survivors will experience both short- and long-term sequelae of treatment, including sub-fertility or infertility. For this reason, many male and female cancer patients will be given the option of sperm, egg, embryo or ovarian tissue cryopreservation before commencing their treatment to protect or restore fertility in the future; this is also true for benign conditions affecting women, such as endometriosis, dermoids, fibroids and autoimmune/haematological diseases.

This Special Issue aims to present the latest advances in the cross-disciplinary field of oncofertility. We welcome contributions from all specialists involved in the different options of fertility preservation in male and female patients affected by benign and malignant conditions that can impair their fertility in future.

For the publication of the previous edition, please see https://www.mdpi.com/journal/life/special_issues/ZIOIO70963.

Dr. Arianna D’Angelo
Dr. Suman Dadhich
Dr. Ali Thwaini
Guest Editors

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Published Papers (1 paper)

Review

14 pages, 1025 KiB

Open AccessReview

Fertility Preservation in BRCA1/2 Germline Mutation Carriers: An Overview

by Erica Silvestris, Gennaro Cormio, Vera Loizzi, Giacomo Corrado, Francesca Arezzo and Easter Anna Petracca

Life 2024, 14(5), 615; https://doi.org/10.3390/life14050615 - 10 May 2024

Viewed by 522

Abstract

BRCA1 and BRCA2 mutations are responsible for a higher incidence of breast and ovarian cancer (from 55% up to 70% vs. 12% in the general population). If their functions have been widely investigated in the onset of these malignancies, still little is known about their role in fertility impairment. Cancer patients treated with antineoplastic drugs can be susceptible to their gonadotoxicity and, in women, some of them can induce apoptotic program in premature ovarian follicles, progressive depletion of ovarian reserve and, consequently, cancer treatment-related infertility (CTRI). BRCA variants seem to be associated with early infertility, thus accelerating treatment impairment of ovaries and making women face the concrete possibility of an early pregnancy. In this regard, fertility preservation (FP) procedures should be discussed in oncofertility counseling—from the first line of prevention with risk-reducing salpingo-oophorectomy (RRSO) to the new experimental ovarian stem cells (OSCs) model as a new way to obtain in vitro-differentiated oocytes, several techniques may represent a valid option to BRCA-mutated patients. In this review, we revisit knowledge about BRCA involvement in lower fertility, pregnancy feasibility, and the fertility preservation (FP) options available. Full article

(This article belongs to the Special Issue Fertility Preservation in Female and Male Benign and Malignant Conditions: 2nd Edition)

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