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Journals
Nutrients
Special Issues
Nutrition and Cancer: From Prevention to After-Care
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Nutrition and Cancer: From Prevention to After-Care

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 487

Special Issue Editor

Prof. Dr. Zhenhua Liu

E-Mail Website
Guest Editor
1. Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
2. UMass Cancer Center, Chan Medical School, University of Massachusetts, Worcester, MA 01655, USA
Interests: micronutrients; dietary bioactive components; traditional chinese medicine; nutritional epigenetics; obesity and inflammation; gastrointestinal health; cancer prevention

Special Issue Information

Dear Colleagues,

The prevalence of cancer is anticipated to steadily increase in the upcoming years, paralleled by a notable rise in the number of cancer survivors, owing to improved survival rates in recent decades. Cancer development is intricately influenced by a range of genetic, environmental and lifestyle factors. Notably, nutrition emerges as a malleable and impactful component, serving as both a protective barrier against the initiation of cancer and a complementary therapeutic tool in its management. This in-depth exploration into the intersection of nutrition and cancer will cover the entire spectrum, from pre-diagnosis to survivorship.

We invite contributions from various research domains, including laboratory studies, epidemiological investigations and comprehensive reviews, delving into the roles played by diet, nutrition, bioactive components in foods and lifestyle factors. These studies aim to elucidate how these elements can prevent the onset of cancer, aid individuals in overcoming treatment-related side effects and enhance the overall quality of life for cancer survivors. We welcome you to join us on this journey as we navigate the evolving terrain of nutrition and cancer, seeking insights that empower individuals to make informed dietary choices regarding the prevention treatment and optimal care post-cancer.

Prof. Dr. Zhenhua Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer prevention, treatment and post-care
  • diet and nutrition
  • foods and dietary bioactive components
  • traditional Chinese medicine
  • obesity

Published Papers (1 paper)

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Research

25 pages, 11130 KiB  
Article
Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection
by Daniel Centeno, Sadaf Farsinejad, Elena Kochetkova, Tatiana Volpari, Aleksandra Gladych-Macioszek, Agnieszka Klupczynska-Gabryszak, Teagan Polotaye, Michael Greenberg, Douglas Kung, Emily Hyde, Sarah Alshehri, Tonja Pavlovic, William Sullivan, Szymon Plewa, Helin Vakifahmetoglu-Norberg, Frederick J. Monsma, Jr., Patricia A. J. Muller, Jan Matysiak, Mikołaj Piotr Zaborowski, Analisa DiFeo, Erik Norberg, Laura A. Martin and Marcin Iwanickiadd Show full author list remove Hide full author list
Nutrients 2024, 16(12), 1816; https://doi.org/10.3390/nu16121816 (registering DOI) - 9 Jun 2024
Viewed by 151
Abstract
Taurine, a non-proteogenic amino acid and commonly used nutritional supplement, can protect various tissues from degeneration associated with the action of the DNA-damaging chemotherapeutic agent cisplatin. Whether and how taurine protects human ovarian cancer (OC) cells from DNA damage caused by cisplatin is [...] Read more.
Taurine, a non-proteogenic amino acid and commonly used nutritional supplement, can protect various tissues from degeneration associated with the action of the DNA-damaging chemotherapeutic agent cisplatin. Whether and how taurine protects human ovarian cancer (OC) cells from DNA damage caused by cisplatin is not well understood. We found that OC ascites-derived cells contained significantly more intracellular taurine than cell culture-modeled OC. In culture, elevation of intracellular taurine concentration to OC ascites-cell-associated levels suppressed proliferation of various OC cell lines and patient-derived organoids, reduced glycolysis, and induced cell protection from cisplatin. Taurine cell protection was associated with decreased DNA damage in response to cisplatin. A combination of RNA sequencing, reverse-phase protein arrays, live-cell microscopy, flow cytometry, and biochemical validation experiments provided evidence for taurine-mediated induction of mutant or wild-type p53 binding to DNA, activation of p53 effectors involved in negative regulation of the cell cycle (p21), and glycolysis (TIGAR). Paradoxically, taurine’s suppression of cell proliferation was associated with activation of pro-mitogenic signal transduction including ERK, mTOR, and increased mRNA expression of major DNA damage-sensing molecules such as DNAPK, ATM and ATR. While inhibition of ERK or p53 did not interfere with taurine’s ability to protect cells from cisplatin, suppression of mTOR with Torin2, a clinically relevant inhibitor that also targets DNAPK and ATM/ATR, broke taurine’s cell protection. Our studies implicate that elevation of intracellular taurine could suppress cell growth and metabolism, and activate cell protective mechanisms involving mTOR and DNA damage-sensing signal transducti. Full article
(This article belongs to the Special Issue Nutrition and Cancer: From Prevention to After-Care)
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