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Nutrients
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Iron Homeostasis in Women across the Lifespan in Health and...
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Iron Homeostasis in Women across the Lifespan in Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 25 November 2024 | Viewed by 1524

Special Issue Editors

Dr. Jane Shearer

E-Mail Website
Guest Editor
Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, Canada
Interests: nutrition; metabolism; physical activity; women’s health; pregnancy
Special Issues, Collections and Topics in MDPI journals
Dr. Martin MacInnis

E-Mail Website
Guest Editor
Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada
Interests: iron homeostasis; altitude; blood volume; oxygen transport; hemoglobin
Dr. Keely Shaw

E-Mail Website
Guest Editor
Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada
Interests: diet; nutrition; supplement; athlete; exercise; performance

Special Issue Information

Dear Colleagues,

Globally, it is estimated that one in three women have sub-optimal iron levels and/or iron deficiency anemia. This Special Issue will consider iron regulation and homeostasis at all life stages from infancy and childhood to pregnancy, menopause and aging. In infants and children, sub-optimal iron can lead to delayed growth and development, immune impairments, and neurological consequences. In young women, there are interactions between hormonal changes and sub-optimal iron levels that are especially prevalent in athletes and affect performance. During pregnancy, iron homeostasis is critical, and deficiency poses risks to fetal development as well as child and maternal outcomes. Iron deficiency can also affect women in middle-age due to menstrual irregularities associated with menopause, fluctuating hormone levels, and the adoption of poor physical activity and dietary habits. Lastly, aging results in reduced iron absorption and differential iron demands with the onset of chronic disease. The first line treatment for sub-optimal iron status is oral supplementation. Reviews and original reports related to iron intake, biochemistry, and consequences of sub-optimal iron levels in varied populations are encouraged. Likewise, iron supplementation strategies including the dosing, timing, side-effects, interaction with the diet and other systems (e.g. gut microbiota) and physical activity are also welcome.

Dr. Jane Shearer
Dr. Martin MacInnis
Dr. Keely Shaw
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • iron
  • anemia
  • women
  • adolescent
  • lifecycle
  • pregnancy
  • athlete
  • menopause
  • supplementation

Published Papers (1 paper)

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Research

12 pages, 1673 KiB  
Article
Dose-Responsive Effects of Iron Supplementation on the Gut Microbiota in Middle-Aged Women
by Jane Shearer, Shrushti Shah, Martin J. MacInnis, Grace Shen-Tu and Chunlong Mu
Nutrients 2024, 16(6), 786; https://doi.org/10.3390/nu16060786 - 10 Mar 2024
Viewed by 1360
Abstract
Oral iron supplementation is the first-line treatment for addressing iron deficiency, a concern particularly relevant to women who are susceptible to sub-optimal iron levels. Nevertheless, the impact of iron supplementation on the gut microbiota of middle-aged women remains unclear. To investigate the association [...] Read more.
Oral iron supplementation is the first-line treatment for addressing iron deficiency, a concern particularly relevant to women who are susceptible to sub-optimal iron levels. Nevertheless, the impact of iron supplementation on the gut microbiota of middle-aged women remains unclear. To investigate the association between iron supplementation and the gut microbiota, healthy females aged 40–65 years (n = 56, BMI = 23 ± 2.6 kg/m2) were retrospectively analyzed from the Alberta’s Tomorrow Project. Fecal samples along with various lifestyle, diet, and health questionnaires were obtained. The gut microbiota was assessed by 16S rRNA sequencing. Individuals were matched by age and BMI and classified as either taking no iron supplement, a low-dose iron supplement (6–10 mg iron/day), or high-dose iron (>100 mg/day). Compositional and functional analyses of microbiome data in relation to iron supplementation were investigated using various bioinformatics tools. Results revealed that iron supplementation had a dose-dependent effect on microbial communities. Elevated iron intake (>100 mg) was associated with an augmentation of Proteobacteria and a reduction in various taxa, including Akkermansia, Butyricicoccus, Verrucomicrobia, Ruminococcus, Alistipes, and Faecalibacterium. Metagenomic prediction further suggested the upregulation of iron acquisition and siderophore biosynthesis following high iron intake. In conclusion, adequate iron levels are essential for the overall health and wellbeing of women through their various life stages. Our findings offer insights into the complex relationships between iron supplementation and the gut microbiota in middle-aged women and underscore the significance of iron dosage in maintaining optimal gut health. Full article
(This article belongs to the Special Issue Iron Homeostasis in Women across the Lifespan in Health and Disease)
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