Oxidative Stress in Hemoglobin and Red Blood Cells

Dear Colleagues,

Oxidative stress has a multitude of effects on the physiology of hemoglobin and red blood cells, with profound consequences for both health and disease. Hemoglobin, the protein responsible for oxygen transport in the blood, is highly susceptible to oxidative damage due to its constant exposure to oxygen and reactive oxygen species. Exposure to oxidative stress can induce various molecular and structural alterations in red blood cells, thereby compromising their function. This oxidative damage not only impairs the oxygen-carrying capacity of red blood cells, but also triggers a cascade of cellular responses, including inflammation and cell death. Furthermore, oxidative stress in red blood cells can exacerbate conditions such as anemia, cardiovascular disease, and even accelerate the ageing process in vivo and during storage. Understanding the mechanisms underlying oxidative stress in hemoglobin and red blood cells is crucial for developing targeted interventions that mitigate its harmful effects and improve overall health outcomes. This Special Issue is focused on the effects of oxidative stress on red blood cells and hemoglobin. We will consider in vitro, translational and clinical studies from all (bio)medical fields. Through this collection of studies, our aim is to promote a deeper understanding of the complex mechanisms underlying oxidative stress in hemoglobin and red blood cells, providing insights that may pave the way for future therapeutic interventions and medical advances.

Dr. David Baron
Guest Editor

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• oxidative stress
• transfusion
• red blood cells/erythrocytes
• hemoglobin
• hematology