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Pathogens
Special Issues
Neuropathogenesis of Arboviruses
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Neuropathogenesis of Arboviruses

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Emerging Pathogens".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 1091

Special Issue Editor

Prof. Dr. Tian Wang

E-Mail Website
Guest Editor
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
Interests: emerging and re-emerging RNA viruses; host immunity; neuropathogenesis; vaccine development; antiviral agents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Arboviruses (arthropod-borne viruses), which are transmitted through the bite of blood-feeding arthropods like mosquitoes, ticks, and sandflies, can trigger neurological disorders. These include encephalitis, paralysis, ophthalmological impairments, developmental defects, or neurological sequelae. Neurological disease caused by arboviral infections often affects young, elderly, and immunocompromised individuals and is becoming a growing public health issue globally. However, the neuropathogenesis of arboviruses is still largely unknown. 

The Special Issue aims to present the latest research on all aspects of the neuropathogenesis of arboviruses. Developing a better understanding of virus–host interactions in the nervous system will be crucial for the development of new therapeutics. Manuscripts of all types are welcome, including reviews, research articles, and short communications. We look forward to your valuable contributions.

Prof. Dr. Tian Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vector-borne viruses
  • encephalitis
  • arboviruses
  • neuropathogenesis
  • neuroinvasive
  • neurovirulence
  • blood–brain barrier
  • neuroinflammation
  • flavivirus
  • alphavirus

Published Papers (1 paper)

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Research

15 pages, 1959 KiB  
Article
VEEV TC-83 Triggers Dysregulation of the Tryptophan–Kynurenine Pathway in the Central Nervous System That Correlates with Cognitive Impairment in Tg2576 Mice
by Chanida Fongsaran, Kelly T. Dineley, Slobodan Paessler and Irma E. Cisneros
Pathogens 2024, 13(5), 397; https://doi.org/10.3390/pathogens13050397 - 9 May 2024
Viewed by 624
Abstract
Neurodegenerative diseases are chronic conditions affecting the central nervous system (CNS). Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid beta in the limbic and cortical brain regions. AD is presumed to result from genetic abnormalities or environmental factors, [...] Read more.
Neurodegenerative diseases are chronic conditions affecting the central nervous system (CNS). Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid beta in the limbic and cortical brain regions. AD is presumed to result from genetic abnormalities or environmental factors, including viral infections, which may have deleterious, long-term effects. In this study, we demonstrate that the Venezuelan equine encephalitis virus (VEEV) commonly induces neurodegeneration and long-term neurological or cognitive sequelae. Notably, the effects of VEEV infection can persistently influence gene expression in the mouse brain, suggesting a potential link between the observed neurodegenerative outcomes and long-term alterations in gene expression. Additionally, we show that alphavirus encephalitis exacerbates the neuropathological profile of AD through crosstalk between inflammatory and kynurenine pathways, generating a range of metabolites with potent effects. Using a mouse model for β-amyloidosis, Tg2576 mice, we found that cognitive deficits and brain pathology were more severe in Tg2576 mice infected with VEEV TC-83 compared to mock-infected controls. Thus, during immune activation, the kynurenine pathway plays a more active role in the VEEV TC-83-infected cells, leading to increases in the abundance of transcripts related to the kynurenine pathway of tryptophan metabolism. This pathway generates several metabolites with potent effects on neurotransmitter systems as well as on inflammation, as observed in VEEV TC-83-infected animals. Full article
(This article belongs to the Special Issue Neuropathogenesis of Arboviruses)
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