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Pharmaceutics
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Advances in Drug Delivery Systems of Plant Extracts for Antibacterial...
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Advances in Drug Delivery Systems of Plant Extracts for Antibacterial and Antioxidant Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 334

Special Issue Editors

Prof. Dr. Montse Mitjans Arnal

E-Mail Website
Guest Editor
Physiology, Department of Biochemistry and Physiology, Universitat de Barcelona, 08028 Barcelona, Spain
Interests: study of antioxidants of natural origin; development of models of ocular and dermal irritation in vitro; development of skin sensitization models in vitro; nanotoxicology
Special Issues, Collections and Topics in MDPI journals
Dr. Paulina Żarnowiec

E-Mail Website
Guest Editor
Department of Microbiology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland
Interests: antibacterial and antifungal activities; biofilm Inhibition; plant extracts in microbiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We cordially invite you to contribute to our Special Issue titled "Advances in Drug Delivery Systems of Plant Extracts for Antibacterial and Antioxidant Applications", which aims at bridging the gap between traditional pharmacology and the cutting-edge science of pharmaceutics. This Special Issue will focus on the innovative use of plant extracts in developing advanced drug delivery systems, formulations, and dosage forms to enhance the efficacy, stability, and patient compliance of treatments with antibacterial and antioxidant properties.

The increasing resistance to conventional antibiotics and the side effects associated with synthetic antioxidants have propelled the search for alternative solutions. This Special Issue seeks to uncover the potential of plant extract drugs not just from a pharmacological perspective but also within the realms of pharmaceutical formulation, drug delivery technologies, and biopharmaceutics.

We are looking for high-quality research articles, reviews, and case studies that contribute to the development of novel drug delivery systems incorporating plant extracts. Topics of interest include, but are not limited to, the identification and characterization of active compounds, the design and optimization of delivery systems (such as nanoparticles, liposomes, or hydrogels), pharmacokinetic studies, drug-releasing behavior, stability analysis, and the evaluations of clinical efficacy and safety. Contributions exploring interdisciplinary research involving engineering, biomedical sciences, and cell biology in the context of plant extract drug delivery are particularly welcome.

Our goal is to compile at least ten articles that demonstrate the relevance and application of these natural compounds in modern drug delivery systems. There is a possibility for the Special Issue to be printed in book form.

We eagerly await your innovative contributions.

Prof. Dr. Montse Mitjans Arnal
Dr. Paulina Żarnowiec
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • drug delivery systems
  • pharmaceutical formulation
  • antibacterial and antioxidant applications
  • pharmacokinetics
  • biopharmaceutics
  • nanoparticles
  • liposomes
  • hydrogels

Published Papers (1 paper)

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Research

19 pages, 1026 KiB  
Article
Protium spruceanum Extract Enhances Mupirocin Activity When Combined with Nanoemulsion-Based Hydrogel: A Multi-Target Strategy for Treating Skin and Soft Tissue Infections
by Tatiane Roquete Amparo, Lucas Resende Dutra Sousa, Viviane Flores Xavier, Janaína Brandão Seibert, Débora Luiza Paiva, Débora dos Santos da Silva, Luiz Fernando de Medeiros Teixeira, Orlando David Henrique dos Santos, Paula Melo de Abreu Vieira, Gustavo Henrique Bianco de Souza and Geraldo Célio Brandão
Pharmaceutics 2024, 16(6), 700; https://doi.org/10.3390/pharmaceutics16060700 - 23 May 2024
Viewed by 193
Abstract
The treatment of skin and soft tissue infections (SSTIs) can be challenging due to bacterial resistance, particularly from strains like MRSA and biofilm formation. However, combining conventional antibiotics with natural products shows promise in treating SSTIs. The objective of this study is to [...] Read more.
The treatment of skin and soft tissue infections (SSTIs) can be challenging due to bacterial resistance, particularly from strains like MRSA and biofilm formation. However, combining conventional antibiotics with natural products shows promise in treating SSTIs. The objective of this study is to develop a nanoemulsion-based hydrogel containing Protium spruceanum extract and mupirocin and evaluate its potential for the treatment of SSTIs. The nanoemulsion was obtained by phase inversion and subsequently characterized. The antibacterial activity was evaluated in vitro against S. aureus MRSA, including the synergism of the combination, changes in membrane permeability using flow cytometry, and the anti-biofilm effect. In addition, the irritative potential was evaluated by the HET-CAM assay. The combination exhibited synergistic antibacterial activity against S. aureus and MRSA due to the extract enhancing membrane permeability. The hydrogel demonstrated suitable physicochemical properties, inhibited biofilm formation, and exhibited low irritation. The formulation was nanometric (176.0 ± 1.656 nm) and monodisperse (polydispersity index 0.286 ± 0.011). It exhibited a controlled release profile at 48 h and high encapsulation efficacy (94.29 ± 4.54% for quercitrin and 94.20 ± 5.44% for mupirocin). Therefore, these findings suggest that the hydrogel developed could be a safe and effective option for treating SSTIs. Full article
(This article belongs to the Special Issue Advances in Drug Delivery Systems of Plant Extracts for Antibacterial and Antioxidant Applications)
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